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Hand et al., 2006

A 2017 clinical study revealed benefits of oral administration of glutathione

If the plasma level is in the high-risk region of the nomogram, the risk of developing hepatotoxicity is 60% or higher, and antidote therapy is warranted

Topical treatments often pair glutathione with other actives like vitamin C, niacinamide, or alpha arbutin for synergy, and can be a good adjunct to oral or IV therapy